You are not sick and nothing is wrong. There is just less in the tank by mid afternoon than there used to be, and recovery takes two days where it used to take one. You bought NMN because you read the research. What most people never check is whether the bottle contains the amount that research used, or how much of the powder is actually NMN.
NMN is one molecule, so a bottle has exactly two things to get right. How much is in the capsule, and whether the powder is still NMN. The human trials that raised blood NAD+ ran from 250 to 900 mg a day, and the middle of that range, 500 to 600 mg, is where the measured changes held up best. On the 29 labels we read, 21 put 300 mg or less in each capsule. Some ask you to take two. Some do not. Either way, the number on the front is not the number in your hand.
Purity is the second half. NMN is expensive to make and unstable if it is made or stored badly, and degraded powder weighs exactly the same in a capsule. 11 of the 29 labels print no purity figure at all. 4 more stop at 98%. A percentage on the panel, backed by a lab test, is the only way to know that 500 mg is 500 mg of NMN.
Then there is what else got in. 8 of the 29 are stacks: NMN plus TMG, resveratrol or a longevity blend. The capsule space is shared, so the NMN number shrinks. 5 of the 29 still use a gelatin shell. One formula of 29 printed 500 mg of NMN in a single plant-cellulose capsule at a stated purity of 99.9%, with nothing else inside.
Took NMN for months and felt nothing? Count the capsules first.Most of the disappointment here is arithmetic. A 250 mg capsule once a day is half of what the trials used, and a stack with a big number on the front may hold less NMN than you think. Read the milligrams per capsule, then read the purity figure. If either one is missing, that is your answer.